Development and Evaluation of Fast Disintegrating Extended Release Tablets Containing Antihypertensive Drug"

Objective: The aim of this work was preparing once daily fast disintegrating tablets to handle easily for adult hypertensive patients who have difficulty in swallowing. Methods: Solid dispersions bisoprolol hemifumarate (SD-BH) was prepared by using EC and HPMC in different ratios. A 3* 22 full factorial design was used to investigate the main formulation parameters (different fillers, binder differ in the molecular weight and different coat type). SD-BH were prepared and characterized by DSC. Disintegration time, wetting properties, friability, and hardness of FDTs were evaluated. Percent drug dissolved was determined. Furthermore, the bioavailability was compared with commercial market product. Results: The mean production yield of BH-SDs was 93.50 ± 0.39 %. The tablets demonstrated a hardness of 2-5 N, friability 0.04-0.56% and disintegration time of 67 ± 1.54 sec. The formulations were subjected to accelerated stability study as per ICH guidelines and were found to be stable after three weeks at 60 °C and 75 % R.H. Conclusion: Based on The present study; the suggested FDTs (Ta1) which delivers a solid dispersions' 10 mg BH using HPMC and EC in 1:1 ratio showed an extended effect in lowering the blood pressure and decrease the disintegrating time lesser than commercial oral tablets.